Contrarily, at physiological concentrations, resveratrol induces vasodilation, and consequently decreases hypertension and cardiovascular diseases risk 79. On the other hand, these results have also confirmed the uses of Polygonum cuspidatum as a resveratrol source to treat and to prevent hyperlipidemia and arteriosclerosis in traditional chinese medicine 80,81,82. Overall, the cardiovascular protective effect of resveratrol have been linked to multiple molecular targets and might be useful to the development of novel therapy for atherosclerosis, metabolic syndrome, ischemia/reperfusion, and heart failure 83.
Medical
Yan et al. suggest that resveratrol act by preventing the expressions of endothelial nitric oxide synthase, vascular endothelial growth factor, and suppressing phosphorylation of p38 in rats with diabetes-related myocardial infarction 73. In addition, resveratrol significantly reduced inflammation factors and malondialdehyde levels, which is a marker of oxidative stress 77. These results showed that resveratrol treatment can improve cardiovascular function by reducing myocardial ischemia-reperfusion injury, vasodilation and atherosclerosis 78.
Lifestyle Choices to Prevent Kidney Stones
In addition, 3278 individuals did not consume any alcohol, 34 had occasional alcohol consumption, and 62 had frequent alcohol consumption. The analysis of demographic and clinical characteristics was provided based on the alcohol consumption trend and the CKD and non-CKD categorization in Tables 1 and 2, respectively. Therefore, we need more evidence to determine whether abstinence can relieve and heal the kidney damage caused by long-term alcohol consumption and the effects of alcohol abstinence on the prognosis of patients with CKD. Otherwise, at doses of 2.5 g or more per day, side effects may occurs, like nausea, vomiting, diarrhea and liver dysfunction in patients with non-alcoholic fatty liver disease 140. In fact, resveratrol has been found to be safe and well-tolerated at up to 5 g/day, either as a single dose or as fraction of multiple-day dosing schedule 142. However, it is imperative to mention that these studies were done in healthy populations, and that may vary in sick patients.
2 Association between OBS and CKD
- The studies involving humans were approved by NHANES was approved by the Ethics Review Board of the NCHS, and all participants submitted informed consent forms.
- Furthermore, drinkers often like to eat more pickled food and eat less vegetables and fruits, which increases the consumption of salt and cholesterol 119.
- Binary logistic regression analysis was used to evaluate the association between the CKD prevalence (CKD vs. non-CKD) and alcohol consumption trend (not at all, occasionally, and frequently) and other confounding factors.
- Also, a larger cohort study with a more generalizable patient population and properly identified confounders is needed to assess the relationship between low and moderate alcohol intake and hypertension development.
- Therefore, administration of 1000 or 300 mg resveratrol/kg b.w./day did not result in nephrotoxic findings.
- Alcohol consumption, including vodka and red wine, also reduced serum insulin concentrations and enhanced the insulin sensitivity index 24,25.
Specifically, resveratrol is well known biologically active compound synthesized by plants undergoing infectious or ionizing radiation. Renaud and De Lorgeril were the first to relate wine polyphenols such as resveratrol, to the potential health benefits attributed to regular and moderate wine consumption (the so called “French Paradox”) 2. Resveratrol has since received an increasing scientific attention, leading to investigation on its biological activity, and to numerous publications 3.
Subjects that were aged more than 18 years old were selected from the 2001, 2005, and 2009 NHIS. Those with a diagnosis of CKD in the medical insurance record before the interview date were excluded. The follow-up duration began since the interview date and censored on the date of incident CKD, death, or Dec 31, 2013, which ever come first. The information provided in this article is for educational and informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment.
Can drinking alcohol cause kidney failure?
- After subject screening (as shown in Figure 1), 25,118 NHANES participants were included in the study, representing 167.6 million non-institutionalized residents of the US.
- However, excessive drinking- more than four standard drinks per day can cause adverse health effects and damage the kidneys.
- Moreover, women with a lower activity of gastric alcohol dehydrogenase have lower gastric first-pass metabolism of alcohol, which also leads to a higher concentration of alcohol than in men 92.
- The great challenge is to make sense of the condition and find a way to adapt to make it fit around it.
Adopting healthy drinking habits, staying hydrated, and making mindful lifestyle choices can significantly reduce your risk of kidney stones. Remember, it’s all about moderation and maintaining a balanced approach to enjoy life while safeguarding your kidney health. Rather, it is an umbrella term not specifically defined and refers to kidney diseases caused by alcohol use. Alcohol use can increase the risk of glomerulonephritis, a condition in which the kidney’s filtering structures become inflamed and damaged.
The National Health Interview Survey selected participants while using a multistage stratified systematic sampling design. Participant information, including education, income, marriage status, and lifestyle behaviors, were obtained during in-person interviews. The National Health Insurance research database comprises medical information of nearly 99% of Taiwanese people, including ambulatory and inpatient care. Kaartinen et al. found that an abnormal immunoreaction may be related to acetaldehyde, the first metabolite of ethanol, which can form covalent adducts with different proteins to activate the immune response49. Resveratrol is a nutraceutical belonging to stilbenoid group, widely distributed in the plant kingdom and with several therapeutic effects.
In addition, long-term alcohol consumption can lead to injuries of renal tubules 1,2,30,39,51. Na+-K+-ATPase present on the proximal tubular epithelial membrane is important for tubular reabsorption. However, recent studies have demonstrated that its activity is decreased by ROS and lipid peroxidation with the consumption of ethyl alcohol 22,41,52.
Ethyl alcohol and water are the main ingredients of alcohol beverages, but we cannot ignore other bioactivators in liquors, such as polyphenols. Moreover, alcohol-induced renal tubular dysfunction is also reflected in vitamin reabsorption disorders. Subramanian et al. proved that chronic alcohol consumption can significantly inhibit carrier-mediated thiamin and biotin transport across the renal brush border membrane and basolateral membrane 54,55. Diagrammatic representation of resveratrol biphasic activity and gene expression modulation. At nanomolar 124 doses, resveratrol acts as a potent antioxidant, while at micromolar (μM) range, it interacts as agonist or antagonist exhibiting cell proliferation/cytoprotective responses or cytostatic/apoptotic effects, respectively.
Unfortunately, it is problems like these that may discourage people from going to such events. As shown in Table 4, for both genders, participants with hyperuricemia displayed a higher alcohol consumption can be a double-edged sword for chronic kidney disease patients pmc multiple‐adjusted eGFR with increasing alcohol consumption. In addition, we observed that interaction between alcohol consumption and SUA affects eGFR.
Consequently, it is not easy to determine the exact safety range and therapeutic effectiveness of specific resveratrol doses on specific populations. In this sense, before prescribing resveratrol, patients should be properly advised for effective treatment with minimum side effects. Further evaluations are needed before declaring resveratrol as a beneficial compound for human health. Age, diabetes, hypertension, hyperlipidemia, and smoking are traditional risk factors of cardiovascular disease in patients with CKD 15–17.