Furthermore, we adjusted for nearly all potential confounding variables, including age, sex, body mass index, alcohol consumption can be a double-edged sword for chronic kidney disease patients pmc socioeconomic status, vegetables, fruit, smoking, and exercise habits, and comorbidities. This 13-year cohort study revealed that participants with social or regular drinking habits had significantly reduced risk of the development of CKD when compared with non-drinkers. Red wine contains compounds that might contribute to stone formation, but the risk depends on factors like diet and hydration.
3. Relationship between background characteristics and eGFR stratified by gender.
- Also, it has been reported earlier that a critical balance between intracellular hydrogen peroxide (H2O2) and O2– decides cells fate to apoptotic stimuli.
- Furthermore, the cardiovascular-protective effects of estrogen 91,93 should not be overlooked.
- Some clinical studies show that alcohol consumption is an important issue in patients with CKD; approximately 20–36% of patients consume alcohol either occasionally or daily, and the approximate percentage of heavy drinkers among patients with CKD is 10% 10,12–14.
- The stones can remain within the kidneys or travel through the urinary tract, causing discomfort and pain.
- However, measuring these biomarkers requires specialized techniques and is challenging to implement, thus limiting their clinical application.
Adopting healthy drinking habits, staying hydrated, and making mindful lifestyle choices can significantly reduce your risk of kidney stones. Remember, it’s all about moderation and maintaining a balanced approach to enjoy life while safeguarding your kidney health. Rather, it is an umbrella term not specifically defined and refers to kidney diseases caused by alcohol use. Alcohol use can increase the risk of glomerulonephritis, a condition in which the kidney’s filtering structures become inflamed and damaged.
More clinical and experimental studies are needed to confirm the effect of alcohol consumption on CKD. Additionally, the drinking pattern, integral dose of alcohol consumption, differences in alcohol beverages, and various concomitant factors should be considered, as they have a significant influence on the effects of alcohol consumption. First, many studies are based on patients’ routine health checkups, as annual health examinations do not allow researchers to evaluate any fluctuation in serum creatinine and other biomarkers.
Kidney injury secondary to alcohol hepatitis, cirrhosis, and other conditions
Diuresis by inhibiting vasopressin release 53 and impairing acid secretion have also been discovered in alcoholics. In addition, hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, hypophosphatemia, and metabolic acidosis mixed with volume-contracted metabolic alkalosis are common in long-term alcohol consumption. The glomeruli are sensitive to fluctuations of systemic blood pressure (BP), and the RAS is the most important BP control system in the kidneys. However, long-term alcohol consumption can activate the RAS and enhance sympathetic nervous activity, which elevates the systemic BP and destroys the normal structure of the glomeruli. Furthermore, this change is irreversible, and the renal structure cannot return to normal once ethanol stimulation is stopped 26,45. The use of natural products is prevalent among patients who are taking conventional medicines, leading to a higher risk of natural product-drug interactions.
Specifically, resveratrol is well known biologically active compound synthesized by plants undergoing infectious or ionizing radiation. Renaud and De Lorgeril were the first to relate wine polyphenols such as resveratrol, to the potential health benefits attributed to regular and moderate wine consumption (the so called “French Paradox”) 2. Resveratrol has since received an increasing scientific attention, leading to investigation on its biological activity, and to numerous publications 3.
In general, the proximal part of the small intestine is the main site for alcohol absorption. Additionally, the stomach, large intestine, esophagus, and even the mouth can absorb small amounts of ethyl alcohol 21. These insights underscore the critical role of health professionals in guiding informed choices that safeguard our health and promote longevity. If you’re experiencing any of these symptoms, especially severe pain, seeking medical attention promptly is crucial. Many of us are becoming increasingly conscious of the choices we make, especially when it comes to what we eat and drink. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.
2 Creatinine and albumin measurements and CKD
As a result, these substances are more likely to crystallize and form small particles that can eventually grow into kidney stones. The studies involving humans were approved by NHANES was approved by the Ethics Review Board of the NCHS, and all participants submitted informed consent forms. The studies were conducted in accordance with the local legislation and institutional requirements. Alcoholic drink equivalent refers to any beverage containing 0.6 oz or 14 grams of pure alcohol in the US 26-28. It is important to understand this as it encourages drinking sensibly and in moderation as there is no drink of moderation. This then has an impact upon that person’s social life, and then upon how that person feels.
While we know that drinking alcohol doesn’t directly impact one’s development of type 2 diabetes, drinking alcohol can have serious side effects for people who have diabetes or are prone to low blood sugar issues. Drink moderately and always be sure to eat a balanced meal if you are drinking booze, as food can mitigate the effect alcohol has on your glucose levels. Check with your doctor to ensure that you shouldn’t have any adverse reactions and that your medication will not contribute to low blood sugars while drinking alcohol.
Jan 2024 : Review article
As a natural food ingredient, numerous studies have demonstrated that resveratrol possesses a very high antioxidant potential. Resveratrol also exhibit antitumor activity, and is considered a potential candidate for prevention and treatment of several types of cancer. Indeed, resveratrol anticancer properties have been confirmed by many in vitro and in vivo studies, which shows that resveratrol is able to inhibit all carcinogenesis stages (e.g., initiation, promotion and progression).
- Resveratrol can also be used as a protective and/or therapeutic agent, particularly in male infertility cases caused by testicular toxicity.
- In contrast, Menon et al. could not find any adverse or beneficial effects of alcohol consumption on kidney function in the elderly 88.
- Cancer experts strongly recommend not drinking alcohol at all due to its potentially harmful effects on the body.
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Subjects that were aged more than 18 years old were selected from the 2001, 2005, and 2009 NHIS. Those with a diagnosis of CKD in the medical insurance record before the interview date were excluded. The follow-up duration began since the interview date and censored on the date of incident CKD, death, or Dec 31, 2013, which ever come first. The information provided in this article is for educational and informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment.
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It may lead to interactions with various cytochrome P450 (CYP), especially when taken at high doses 150. Resveratrol has been reported to inhibit CYP3A4 activity, in vitro 151 and in healthy volunteers 152. Therefore, high resveratrol intakes even in through form of supplements with additional medications could potentially reduce drugs metabolic clearance that undergo extensive first-pass CYP3A4 metabolism, hence increasing both bioavailability and toxicity risk of these drugs.
Clinical Research
Dehydration, often underestimated, plays a significant role in kidney stone formation.3 Our kidneys filter waste products from our blood and produce urine. When we become dehydrated, the concentration of minerals and salts in our urine can increase, creating an environment conducive to forming kidney stones. In addition to direct associations, this study examined the statistical significance of the interactive relationships using a general linear model with confounding factors (Table 3). The results indicate that the interaction between alcohol consumption and SUA is a significant and independent determinant of eGFR. According to the results of the study, out of 3374 participants, 81.1% had no CKD and 18.9% had CKD.
These results clearly demonstrated that resveratrol derivatives might serve as potential antioxidants in foods and biological systems. Pterostilbene, a natural methoxylated resveratrol analogue, was first isolated from Pterocarpus santalinus (red sandalwood), a plant used in traditional medicine for diabetes treatment 26. This Pterocarpus marsupium active constituent is mainly found in blueberries, grapes, and several plant woods. Pterostilbene has a similar structure to resveratrol except that in A ring 3 and 5 position was replaced by a methoxyl group 26. This compound pro-lipophilicity, greater than that of resveratrol, increases its bioavailability 28,29,30 resulting in stronger bioactivities, including anticancer, anti-lipidemic, antidiabetic, and cardioprotective effects than those of resveratrol 26,31,32.