Additionally, articles published within Cureus should not be deemed a suitable substitute for the advice of a qualified health care professional. Do not disregard or avoid professional medical advice due to content published within Cureus. Your doctor may prescribe proton pump inhibitors or H2 antagonists to reduce the production of stomach acid. It is important to measure your blood pressure before you take your medicine and track it to inform your doctor of how well your blood pressure is controlled. When experts talk about one drink, they are talking about one 12-ounce bottle of beer, one glass of wine (5 ounces), or one shot (1.5 ounces) of “hard liquor.” alcohol consumption can be a double-edged sword for chronic kidney disease patients pmc Always consult your healthcare provider to determine what’s safe for you.
Many patients with CKD often have other comorbidities, such as diabetes, coronary heart disease, stroke, and other serious chronic diseases. In addition, alcohol consumption can contribute to volume overload, hypertension, and electrolyte disorder between hemodialysis sessions in hemodialysis patients, which also should not be ignored. So, alcohol consumption can be a double-edged sword for patients with CKD, and any policy regarding alcohol consumption for them must be very cautious.
Lifestyle Choices to Prevent Kidney Stones
One possible mechanism is oxidative stress resulting from increased production of reactive oxygen species, which leads to an excessive amount of free radicals, which in turn trigger tissue injury and increase inflammation. In addition, AUD’s effect on other major organs (liver, heart, intestines, and skeletal muscle) appears to promote unfavorable pathological processes that are harmful to the kidneys. Additional research is needed to clarify if alcohol does indeed promote kidney injury and the mechanisms by which alcohol-induced kidney injury may occur. There is limited research addressing the association between the alcohol consumption trend and different CKD stages.
Data collection procedure
- Physically, the kidneys have several enzymes with antioxidant capacities, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase, which can balance various oxidative processes.
- This excess calcium can combine with other substances, such as oxalate, and form crystals that become the foundation of kidney stones.
- Resveratrol is widely known for its renowned beneficial biological effects, namely involving its chemopreventive and antioxidant properties.
- Additionally, the stomach, large intestine, esophagus, and even the mouth can absorb small amounts of ethyl alcohol 21.
- Thus, a shift towards H2O2 favors apoptosis, whereas inclination towards O2- obstructs apoptosis.
This can lead to dehydration, which is a significant risk factor for kidney stone formation. Alcohol consumption can have a significant impact on kidney function, particularly in relation to dehydration. The diuretic effect of alcohol leads to increased urine flow, which can disrupt the body’s fluid balance and electrolyte concentrations. This section explores the diuretic effect of alcohol and its implications for kidney health.
Can drinking alcohol cause kidney failure?
One of the reasons for this sex difference might be the different pharmacokinetics of ethyl alcohol between men and women. Since women, with a lower proportion of body water, have a smaller distribution volume for alcohol, they are more likely to have a higher concentration of alcohol in the blood than men. Although studies have proven that even a single dipstick indication of proteinuria is a significant risk for CKD and ESRD 122, a single dipstick detection can be biased by numerous confounders. These include anthocyanins, which are the main polyphenols in red grapes, and resveratrol, which is the most famous polyphenolic compound found in red wine 104. They have been demonstrated to have ROS scavenging, antiplatelet, anticancer, anti-inflammatory, antidiabetic, antibacterial, antiaging, and cardiovascular and renal-protective effects 105–112.
Screening Obstructive Sleep Apnea in Chinese Adults: Optimizing STOP-Bang and NoSAS Cutoff Values
Previous studies showed that hydroxyl group in 4′ position is not the sole determinant for antioxidant activity, but also the 3- and 5-OH groups 40,41. Resveratrol can also be used in minimizing or preventing lipid oxidation in pharmaceutical products, delaying toxic oxidation products formation, and maintaining both nutritional quality and prolonging pharmaceuticals shelf-life 43,44,45. In addition, resveratrol’s antioxidant properties have been successfully employed to protect cells against hydrogen peroxide-induced oxidative stress, where the pre-treatment with resveratrol promoted cell survival and protection against UV-irradiation-induced cell death. Among these families, Dipterocarpaceae, containing 50 resveratrol’s, accounts for the majority, being involved 7 Dipterocarpaceae genera, including Vatica, Vateria, Shorea, Hopea, Neobalanocarpus, Dipterocarpus and Dryobalanops 9.
Resveratrol: A Double-Edged Sword in Health Benefits
Since this polyphenol has been reported to have significant interactions with phase I and II enzymes both in vitro and in vivo 153, they may be beneficial or harmful as well. Indeed, individuals taking drugs, such as tamoxifen, whose efficacy is highly specific and CYP enzymes-dependent, could be particularly affected. Therefore, caution should be taken when using supplemental resveratrol doses for health benefits, such as chemoprevention. As already highlighted, resveratrol is a powerful antioxidant that beneficial effect is hampered by its low bioavailability. Many attempts have been made to generate resveratrol derivatives by esterification process to improve their lipophilicity and application in lipid-based foods and biological environments. These derivatives were able to effectively inhibit copper ion-induced low-density lipoprotein (LDL) oxidation and inhibited hydroxyl radical-induced DNA scission 33.
- It may lead to interactions with various cytochrome P450 (CYP), especially when taken at high doses 150.
- The current study enrolled 45,200 subjects, which was a representative cohort for the Taiwan population.
- Additionally, resveratrol consumption at modest doses result in a life span increase in 1-year old mice.
- However, recent studies have demonstrated that its activity is decreased by ROS and lipid peroxidation with the consumption of ethyl alcohol 22,41,52.
- In this article, we’ll explore the intricate relationship between alcohol consumption and the risk of kidney stones and provide you with insights to make informed choices for your kidney health.
Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. From our experience with individuals living with kidney failure, the key is to live first and be a patient second. The datasets analyzed in this study are available from the corresponding author (Ryuichi Kawamoto, -u.ac.jp) on reasonable request. Medical Science Monitor (MSM) established in 1995 is an international, peer-reviewed scientific journal which publishes original articles Clinical Medicine and related disciplines.
NHANES has received approval from the National Center for Health Statistics Ethics Review Committee, and all participants have provided written informed consent. You’ll feel pain from a kidney problem in your back on the left or right side of your spine. Blood and urine tests, and sometimes imaging tests, can help your doctor find the source of the pain. Despite the multiple possible causes of acidosis, disturbances in acid-base balance are more frequently manifested as low acidity (i.e., alkalosis). Alkalosis was present in 71 percent of patients with established liver disease in 11 studies, and respiratory alkalosis was the most common disturbance in 7 of the studies (Oster and Perez 1996).
Adopting a holistic approach to your lifestyle can significantly impact your kidney health. Alcohol is known for its diuretic effect, which encourages increased urine production and subsequently leads to fluid loss.4 This can be especially pronounced after consuming larger amounts of alcohol or certain types of alcoholic beverages. Before delving into the impact of alcohol, it’s paramount to grasp the fundamentals of kidney stones and their formation.
Some clinical studies show that alcohol consumption is an important issue in patients with CKD; approximately 20–36% of patients consume alcohol either occasionally or daily, and the approximate percentage of heavy drinkers among patients with CKD is 10% 10,12–14. Many studies have confirmed that unhealthy diet and lifestyle can cause various diseases, and heavy alcohol consumption is one of the important factors 66. As an influential factor of many chronic diseases, alcohol consumption has been increasingly studied in recent years. Many studies have shown that alcohol consumption is related to cardiovascular disease, urinary protein, and CKD 3,6,16,45,66–69.
Cheers to Kidney Health: Does Alcohol Up Stone Risk?
After subject screening (as shown in Figure 1), 25,118 NHANES participants were included in the study, representing 167.6 million non-institutionalized residents of the US. Table 1 presents the baseline characteristics of the study participants grouped according to OBS quartiles. The mean age of the participants was 48.29 ± 16.78 years, with 51.67% being female, and the weighted prevalence of CKD was 14.97%. The prevalence of hypertension, diabetes, hyperlipidemia, CVD, depression, and CKD also decreased with increasing OBS. There was no statistically significant difference in gender distribution between the different OBS groups. This study is a nationwide cross-sectional research that draws data from the NHANES conducted during the 2005–2018 survey cycles.